A 385358 ( A385358 )

Catalog No. M14400 CAS No. 406228-55-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

A 385358
Note

Research use only, not for human use.
Brief Description

A 385358 is a potent, selective, cell-permeable Bcl-XL inhibitor with Ki of 0.8 nM.
Description

A 385358 is a potent, selective, cell-permeable Bcl-XL inhibitor with Ki of 0.8 nM, displays >80-fold selectivity over Bcl-2 (Ki=64 nM); shows relatively modest single-agent cytotoxic activity against most tumor cell lines with an EC50 of <500 nM in cells dependent on Bcl-X(L) for survival; enhances the in vitro cytotoxic activity of numerous chemotherapeutic agents; significantly inhibits tumor growth in the A549 xenograft model.
Synonyms

A385358
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

——
Indication

——

CAS Number

406228-55-5
Formula Weight

639.83
Molecular Formula

C32H41N5O5S2
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL195.36 mM
SMILES

O=C(NS(=O)(C1=CC=C(N[C@H](CCN(C)C)CSC2=CC=CC=C2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCC(C)(C)CC4)C=C3
Chemical Name

N-[4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-(4,4-dimethylpiperidin-1-yl)benzamide

1. Wendt MD, et al. J Med Chem. 2006 Feb 9;49(3):1165-81.
2. Shoemaker AR, et al. Cancer Res. 2006 Sep 1;66(17):8731-9.

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