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A 385358

CAS No. 406228-55-5

A 385358 ( A385358 )

Catalog No. M14400 CAS No. 406228-55-5

A 385358 is a potent, selective, cell-permeable Bcl-XL inhibitor with Ki of 0.8 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 461 Get Quote
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Biological Information

  • Product Name
    A 385358
  • Note
    Research use only, not for human use.
  • Brief Description
    A 385358 is a potent, selective, cell-permeable Bcl-XL inhibitor with Ki of 0.8 nM.
  • Description
    A 385358 is a potent, selective, cell-permeable Bcl-XL inhibitor with Ki of 0.8 nM, displays >80-fold selectivity over Bcl-2 (Ki=64 nM); shows relatively modest single-agent cytotoxic activity against most tumor cell lines with an EC50 of <500 nM in cells dependent on Bcl-X(L) for survival; enhances the in vitro cytotoxic activity of numerous chemotherapeutic agents; significantly inhibits tumor growth in the A549 xenograft model.
  • Synonyms
    A385358
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    406228-55-5
  • Formula Weight
    639.83
  • Molecular Formula
    C32H41N5O5S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 125 mg/mL195.36 mM
  • SMILES
    O=C(NS(=O)(C1=CC=C(N[C@H](CCN(C)C)CSC2=CC=CC=C2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCC(C)(C)CC4)C=C3
  • Chemical Name
    N-[4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-(4,4-dimethylpiperidin-1-yl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wendt MD, et al. J Med Chem. 2006 Feb 9;49(3):1165-81.
2. Shoemaker AR, et al. Cancer Res. 2006 Sep 1;66(17):8731-9.
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